David Feldman is a curious amateur medical researcher who has proposed the "lean mass hyper-responder" hypothesis that says some people respond very differently to dietary fat. I'm curious to know if you have comments about his conclusions, such as this evidence that for some people a diet of Oreos can actually *lower* LDL levels, demonstrating that obviously LDL lowering is not the be all and end all:
part 2: As insulin and glucose are though to decrease LDL-R expression and reduce Cholesterol efflux so this oreo hypothesis throws me through a mental kerfuffle
I would love to know the mechanism. I will dig in an try to find it before I sit down with my bag of oreo's. I am familiar with the term hyper responder but not "lean-mass hyper responder"
David Feldman is a curious amateur medical researcher who has proposed the "lean mass hyper-responder" hypothesis that says some people respond very differently to dietary fat. I'm curious to know if you have comments about his conclusions, such as this evidence that for some people a diet of Oreos can actually *lower* LDL levels, demonstrating that obviously LDL lowering is not the be all and end all:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10818743/
part 2: As insulin and glucose are though to decrease LDL-R expression and reduce Cholesterol efflux so this oreo hypothesis throws me through a mental kerfuffle
I would love to know the mechanism. I will dig in an try to find it before I sit down with my bag of oreo's. I am familiar with the term hyper responder but not "lean-mass hyper responder"
this link makes more sense to me. https://www.sciencedirect.com/science/article/pii/S2666667723000892?via%3Dihub